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Assessment and Prediction of Cognitive Impairment in Mild Traumatic Brain Injury

Early Assessment and Prediction of Cognitive Dysfunction in Mild Traumatic Brain Injury Based on the Island-Hippocampal Neural Circuit

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600119450
Enrollment
Unknown
Registered
2026-02-27
Start date
2026-03-01
Completion date
Unknown
Last updated
2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cognitive impairment in mild traumatic brain injury

Interventions

Patients with mild traumatic brain injury group:None
Healthy Controls:None

Sponsors

NanJing First Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Visit within 24 hours after traumatic brain injury and complete relevant imaging and behavioral examinations; 2. Age 18-65; right-handed; 3. All patients were examined and diagnosed by experienced neurologists and met the diagnostic criteria for mTBI proposed by the Mayo Clinic in the United States: a Glasgow Coma Scale score of 13-15 within 24 hours; loss of consciousness <=30 minutes, post-traumatic amnesia <=24 hours, and/or the temporary appearance of one or more neurological abnormalities; excluding intracranial hematomas, penetrating fractures, brain contusions, etc., as shown on routine cranial CT/MRI, with or without transient neurological dysfunction (such as depression, headache, or delirium) or basal skull fractures; improvement without the need for any neurosurgical treatment;

Exclusion criteria

Exclusion criteria: 1. Traumatic brain injury cases involve litigation; 2. Currently or previously suffering from any neurological and/or psychiatric-related disorders; 3. Currently or previously has a history of substance abuse or addiction; 4. History of traumatic brain injury; 5. Contraindications for MRI (such as metal implants in the body, claustrophobia, etc.);

Design outcomes

Primary

MeasureTime frame
Cognitive Function Status and Scores (including Montreal Cognitive Assessment [MoCA] and domain-specific neuropsychological test scores to determine the presence of cognitive impairment);Imaging Features of the Insula-Hippocampus Neural Circuit (including static/dynamic functional connectivity, anatomical connectivity, structural covariance matrix, topological property parameters, and connection gradient metrics);Performance Metrics of Cognitive Impairment Prediction Models (including AUC, sensitivity, specificity, positive and negative predictive values);—

Countries

China

Contacts

Public ContactLu Liyan

NanJing First Hospital

luliyan.ok@163.com+86 25 52271461

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Mar 14, 2026