Labor Analgesia
Conditions
Interventions
Sequential experimental group:The biased coin design (BCD) was adopted to explore the effective dose, with dose adjustments performed at 8, 9, 10, 11, 12 and 13 mL. Each parturient started with a dose
for a non-responsive case (PCEA bolus or clinician-administered bolus required), the dose for the next parturient was increased by 1 mL. The initial dose was defined as 10 mL of 0.1% ropivacaine combi
the single administration dose for the first parturient was set at 8 mL.
Sponsors
Women and Children's Hospital, Qingdao University, Qingdao
Eligibility
Sex/Gender
Female
Age
20 Years to 35 Years
Inclusion criteria
Inclusion criteria: 1. Singleton pregnancy at 37–42 weeks of gestation, nulliparous pregnant women; 2. Aged 20–35 years; 3. American Society of Anesthesiologists (ASA) physical status classification ?–?; 4. Cervical dilation of 2–3 cm with a Visual Analogue Scale (VAS) score of >=6 points; 5. Before the trial, the patients were fully informed of the nature, significance, potential benefits, possible inconveniences and potential risks of the trial, understood the research procedures, and voluntarily signed the informed consent form in writing.
Exclusion criteria
Exclusion criteria: 1.Age 35 years, parous women, advanced maternal age, multiple pregnancy; 2. Morbid obesity, pregnancy-related disorders (i.e., gestational diabetes mellitus, gestational hypertension, and preeclampsia); 3. History of substance abuse, contraindications to neuraxial block; 4. Hypersensitivity to the study drugs; 5. Conditions increasing the risk of cesarean section (i.e., placenta previa, history of uterine anomalies or uterine surgery) and known fetal anomalies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effective analgesic; | — |
Secondary
| Measure | Time frame |
|---|---|
| Visual analogue scale score;Modified Bromage Scale;Adverse reaction;Sedation Score: Ramsay Sedation Score; | — |
Countries
China
Contacts
Public ContactYongxin Liang
Women and Children's Hospital, Qingdao University, Qingdao
Outcome results
None listed