Type 2 Diabetes Mellitus
Conditions
Interventions
Healthy control group:None
Sponsors
NanJing First Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. T2DM Group: (1) Aged 18-65 years, meeting the WHO (1999) diagnostic criteria for T2DM. (2) Glycated hemoglobin (HbA1c) between 7.5% and 10.0%. (3) On a stable glucose-lowering regimen for >= 3 months. (4) Voluntary participation and provision of signed informed consent. 2. Healthy Control Group: (1) Aged 18-65 years, with fasting blood glucose <6.1 mmol/L and HbA1c <5.7%. (2) Body mass index (BMI) 18.5-24.0 kg/m^², with no personal or family history of diabetes. (3) Frequency-matched to the T2DM group in age (+-5 years) and gender. (4) Voluntary participation and provision of signed informed consent.
Exclusion criteria
Exclusion criteria: (1). Type 1 diabetes or other specific types of diabetes. (2) History of major gastrointestinal surgery or active severe gastrointestinal disease. (3) Use of GLP-1 receptor agonists or DPP-4 inhibitors within the past 3 months. (4) Contraindications to MRI examination (e.g., claustrophobia, incompatible implants). (5) Severe cardiac, hepatic, or renal insufficiency. (6) Pregnancy or lactation. (7) Any other condition deemed by the investigator as unsuitable for participation in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Duodenal mucosal characteristics (K-cell density, GIP expression intensity);Circulating hormone levels (fasting plasma GIP concentration),;Central nervous system function (hypothalamic insulin sensitivity ?CBF measured by fMRI); | — |
Secondary
| Measure | Time frame |
|---|---|
| Duodenal Transcriptome Features;Correlation between main indicators and clinical metabolic parameters; | — |
Countries
China
Contacts
Public ContactXuetian Qian
NanJing First Hospital
Outcome results
None listed