Effects of Salivary Microbiota on Taste Perception and Food Preferences in School-Age Children with Obesity and Validation in a Mouse Model

Screening of Specific Salivary Microbial Strains Associated with Obesity in School-age Children and Functional Validation of Their Effects on Taste Perception and Food Preferences in Mouse Models

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2600119435

Enrollment

Unknown

Registered

2026-02-27

Start date

2026-03-01

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

obesity

Interventions

Obesity children group:None

Normal weight children group:None

Eligibility

Sex/Gender

All

Age

6 Years to 12 Years

Inclusion criteria

Inclusion criteria: 1.School-age children, 6-12 years old; 2.Diagnosis of obesity, with BMI >= 95th percentile; 3.Normal body size, with BMI between the 5th and 85th percentiles; 4. Provision of assent/consent (along with parental or guardian consent) to provide saliva samples and participate in the follow-up study.

Exclusion criteria

Exclusion criteria: 1. Use of antibiotics / systemic antimicrobial agents within the past 3 months, or long-term oral medication (e.g., chronic hormonal therapy). 2. Extensive dental treatment or acute flare-up of oral inflammation within the recent month. 3. Presence of severe systemic diseases (e.g., congenital metabolic disorders, severe immunodeficiency, digestive system diseases). 4. Refusal or inability to cooperate with the sampling procedure.

Design outcomes

Primary

Measure	Time frame
16S rRNA sequencing of the microbiota;	—

Countries

China

Contacts

Public ContactXin Zhang

The First Affiliated Hospital of Dalian Medical University

zhang_xin_85@126.com+86 411 83635963

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Mar 14, 2026