Pre-chronic obstructive pulmonary disease, Pre-COPD
Conditions
Interventions
Observation group 1 (healthy subjects without cigarette smoke exposure):N/A
Observation group 2 (smokers who did not meet the diagnostic criteria for copd):N/A
Observation group 3 (mild COPD patients):N/A
Observation group 4 (moderate COPD patients):N/A
Observation Group 5 (patients with severe COPD):N/A
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
40 Years to No maximum
Inclusion criteria
Inclusion criteria: Inclusion criteria: 1 Healthy subjects without exposure to cigarette smoke (1) Age: 40 years old; (2) no smoking history or smoking history =0.70; 2 Smokers who did not meet the diagnostic criteria for COPD (1) Age: >=40 years; (2) smoking history: >=10 pack-years, and current smokers or quit smoking less than 1 year; (3) post-bronchodilator FEV1/FVC>=0.70; 3 Patients with different degrees of COPD (1) Age: >=40 years; (2) smoking history: >=10 pack-years, and current smokers or quit smoking less than 1 year; (3) post-bronchodilator FEV1/FVC= 80% predicted value; Moderate (GOLD stage I) : 50% <= FEV1 < 80% predicted; Severe or greater (GOLD stage III and IV) : FEV1 < 50% of predicted value.
Exclusion criteria
Exclusion criteria: Exclusion criteria: 1. Other pulmonary diseases such as documented chronic asthma, allergic bronchopulmonary aspergillosis (ABPA), active or actively treated pulmonary Mycobacterium tuberculosis (TB), nontuberculous Mycobacterium (NTM) infection, bronchiectasis, interstitial lung disease, etc.; 2. Suffering from other chronic diseases (such as malignant diseases such as tumors, diabetes, cardiovascular diseases); 3. Use of inhaled corticosteroids (ICS) or hormone drugs or antibiotics in the past 1 month; 4. Pulmonary infection in the past one month; 5. occurrence of myocardial infarction, cerebrovascular accident, major surgery and other events in the past 3 months; 6. Terminal stage of disease or waiting for organ transplantation; 7. Women who are pregnant, breastfeeding, or planning to become pregnant in the following year or who could become pregnant but declined to use contraception for at least 1 month before enrollment and throughout the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quality-of-life SCORES;Pulmonary function;Imaging Studies(CTSPECT);IOS Testing; | — |
Countries
China
Contacts
Public ContactFuqiang Wen
West China Hospital, Sichuan University
Outcome results
None listed