Chemotherapy-related lung injury
Conditions
Interventions
No chemotherapy group:N/A
Sponsors
Jiangsu Province Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: 1. Age between 18 and 75 years old, with no gender restrictions; 2. Pathologically diagnosed with lung cancer or lung metastatic cancer, and scheduled for lung lobe resection surgery; 3. Neoadjuvant chemotherapy group: received at least 2 cycles of a double-drug regimen containing platinum-based drugs as neoadjuvant chemotherapy before the surgery; 4. No chemotherapy group: diagnosed and did not receive any chemotherapy or targeted therapy before the surgery, and directly underwent surgical treatment; 5. The patient gave informed consent and signed the informed consent form.
Exclusion criteria
Exclusion criteria: Exclusion Criteria: 1. Presence of significant respiratory/circulatory system diseases before surgery, such as definite interstitial lung disease, chronic obstructive pulmonary disease (GOLD grade 3 or above), severe pulmonary hypertension, or heart failure; 2. Severe autoimmune diseases or long-term use of immunosuppressants; 3. Active pulmonary infection before surgery; 4. Inability to cooperate with the study or provide informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| levels of Neutrophil Extracellular Traps(NETs); | — |
Secondary
| Measure | Time frame |
|---|---|
| levels of Piezo1 channel protein;levels of TRPV4 channel protein;the expression level of NLRP3 protein;the expression level of Interleukin-1 beta(IL-1ß);the expression level of Interleukin-18(IL-18); | — |
Countries
China
Contacts
Public ContactLinjia Zhu
Jiangsu Province Hospital/The First Affiliated Hospital of Nanjing Medical University
Outcome results
None listed