Liver disease
Conditions
Interventions
Remimazolam group (Group R):Remimazolam induction (0.15 mg/kg) and maintenance (0.5 - 1 mg/kg/h)
Propofol group (Group P):Propofol induction (2 mg/kg) and maintenance (4 - 6 mg/kg/h)
Sponsors
The Affiliated Hospital of Chengde Medical University
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. No gender restrictions; 2. ASA grade II or III; 3.Age over 60 years old; 4. BMI: 18.5 - 24.9 kg/m2; 5. Child-Pugh grade A; 6. Comply with the surgical indications for laparoscopic liver resection.
Exclusion criteria
Exclusion criteria: 1. Those who have a history of long-term abuse of anesthetic and analgesic drugs, drug abuse, or alcohol abuse before the operation; 2. Those who have hypertension and diabetes before the operation; 3. Those who have a history of severe diseases in the heart, brain, lungs, kidneys, or other important organs or organ failure before the operation; 4. Those who have adrenal gland diseases before the operation; 5. Those who are allergic to the drugs used in the study; 6. Secondary or multiple hepatocellular carcinomas; 7. Those who have previously undergone liver surgery treatment; 8. Those with mental disorders or psychological diseases; 9. Patients with cognitive dysfunction before the operation; 10. Those whose CT measurement of the expected residual liver volume (RLV) before the operation is less than 40%.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mean arterial pressure;heart rate;cardiac index;systemic vascular resistance; regional cerebral oxygen saturation;cerebral desaturation event;jugular bulb venous oxygen saturation;the arterial–internal jugular venous oxygen content difference ; the cerebral oxygen extraction ratio;Mini-mental state examination;montreal cognitive ;Sß100;C-reactive protein;interleukin-6;tumor necrosis factor-a;epinephrine;noradrenaline;cortisol;blood glucose;recovery time;extubation time;Incidence of emergence agitation during recovery period;Post-anesthesia care unit stay time; | — |
Secondary
| Measure | Time frame |
|---|---|
| alanine aminotransferase;aspartate aminotransferase;total bilirubin;albumin;urine volume;blood serum creatinine;blood urea nitrogen;retinol binding protein;cystatin c ;The frequency of intraoperative hypotension occurrence;The total amount of vasopressor drugs used during the operation;The incidence rates of postoperative nausea, vomiting and dizziness;Incidence of induced injection pain;The incidence of bradycardia; | — |
Countries
China
Contacts
Public ContactJianling Li
The Affiliated Hospital of Chengde Medical University
Outcome results
None listed