Postoperative Analgesia for Laparoscopic Radical Gastrectomy
Conditions
Interventions
Group Oxycodone:PCIA:oxycodone 0.8 mg/kg combined with ondansetron 8 mg (mixed in the PCIA pump solution to a volume of 100 mL) (no background infusion, bolus of 2 mL, lockout time of 10 min).
Group Sufentanil:PCIA:sufentanil 2 ug/kg combined with ondansetron 8 mg (mixed in the PCIA pump solution to a volume of 100 mL) (no background infusion, bolus of 2 mL, lockout time of 10 min).
Sponsors
Beijing Friendship Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18 to 75 years old, of either gender. 2. Body Mass Index (BMI): 18 to 30 kg/m². 3. Surgery: Patients scheduled for elective laparoscopic radical gastrectomy. 4. ASA Physical Status: American Society of Anesthesiologists (ASA) physical status I to III. 5. Informed Consent: Patients who provided written informed consent and voluntarily agreed to participate in the study.
Exclusion criteria
Exclusion criteria: 1. Patients who explicitly refused to participate in the study. 2. Body Mass Index (BMI) > 30 kg/m²; or a history of severe cardiovascular, cerebrovascular, pulmonary, hepatic, renal, or metabolic diseases. 3. Long-term use of opioids or analgesics before surgery; or a history of abnormal recovery from previous anesthesia or surgery. 4. Severe hepatic or renal insufficiency (Child-Pugh class C or estimated glomerular filtration rate [eGFR] 1.5 or platelet count < 80 × 10?/L). 7. Presence of skin infection or inflammation at the intended puncture site. 8. Any other condition that, in the investigator's opinion, made the patient unsuitable for the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The 15-item recovery quality scale at 24 hours after surgery (global score Quality of Recovery-15 scale, QoR-15); | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain score;PCIA total compressions ;PCIA effective compressions ;Total opioid consumption from 0 to 24 hours postoperatively will be calculated as intravenous morphine equivalents (IME, mg);Incidence of postoperative nausea and vomiting (PONV);Incidence of sedation;Incidence of respiratory depression ;Time to first flatus;The QoR-15 at 48h after surgery ;Time to first oral intake;The time of removing the gastric tube;The time of removing the urinary catheter;time of first postoperative mobilization ; | — |
Countries
China
Contacts
Public ContactDanxu Ma
Beijing Friendship Hospital, Capital Medical University,
Outcome results
None listed