Helicobacter pylori infection
Conditions
Interventions
Tegoprazan-Amoxicillin group(TA group):Tegoprazan–Amoxicillin dual eradication regimen
Tegoprazan-tetracycline group(TT group):Tegoprazan–tetracycline dual eradication regimen
Tegoprazan-Minocycline group(TM group):Tegoprazan–minocycline dual eradication regimen
Sponsors
Peking University Third Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Male or female aged >=18 and <=75 years; 2. Positive H. pylori test (positive 13C-urea breath test AND at least one of the following three tests positive: Stool H. pylori antigen test; Rapid urease test; Histopathological examination of gastric mucosal biopsy tissue.
Exclusion criteria
Exclusion criteria: 1. Previous eradication therapy for Helicobacter pylori; 2. Use of drugs that may affect the study results within 4 weeks before enrollment (e.g., PPIs, P-CABs, bismuth preparations, antibiotics); 3. Gastrointestinal malignancy; 4. Zollinger-Ellison syndrome; 5. Previous surgery that may affect gastric acid secretion or drug absorption (e.g., partial gastrectomy); 6. Severe underlying systemic disease; 7. allergy to any study drug; 8. Pregnant or lactating women, or alcohol addiction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Helicobacter pylori eradication rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Medication adherence;Incidence of adverse events; | — |
Countries
China
Contacts
Public ContactLiya Zhou
Peking University Third Hospital
Outcome results
None listed