infertility
Conditions
Interventions
Non-sustained pregnancy group:None
sustained pregnancy group:None
Sponsors
The First Affiliated Hospital of Nanjing Medical University (Jiangsu Province People's Hospital)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Recipients of PGT-SR/M euploid blastocyst transfer; 2. Willing to provide fecal and blood specimens during the FET cycle.
Exclusion criteria
Exclusion criteria: 1. Uncorrected disease states affecting embryo implantation and sustained pregnancy, such as moderate to severe hydrosalpinx, uterine malformation, severe adenomyosis, uterine fibroids with diameter =4 cm, endometrial thickness <7 mm on the day of transfer; 2. Uncorrected endocrine/metabolic diseases such as CAH, hypothyroidism/hyperthyroidism, diabetes, or uncorrected autoimmune diseases such as antiphospholipid syndrome, Sjögren's syndrome, rheumatoid arthritis; 3. History of major gastrointestinal surgery and/or bowel resection within the past 5 years; 4. Persistent or infectious gastroenteritis; 5. Use of antibiotics, glucocorticoids, or other medications, as well as dietary supplements such as prebiotics within one month prior to sampling.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ongoing pregnancy rate;biochemical pregnancy rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| embryonic arrest rate;embryo implantation failure rate; | — |
Countries
China
Contacts
Public ContactDiao Feiyang
The First Affiliated Hospital of Nanjing Medical University (Jiangsu Provincial People's Hospital)
Outcome results
None listed