Ankylosing Spondylitis
Conditions
Interventions
Gold Standard:The BASMI is measured using manual methods. It consists of five indicators that assess and score the range of motion in various joints of patients, reflecting the degree of limitation in
2. Lumbar Flexion (Modified Schober’s Test)
3. Lateral Spinal Flexion
4. Intermalleolar Distance
5. Occiput-to-wall and Tragus-to-wall Distance.
Index test:Using image processing technology (automated BASMI measurement system) to measure the five indicators of BASMI.
Sponsors
The Seventh Affiliated Hospital, Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria for Patients with Axial Spondyloarthritis: 1. Age Requirement: Male or female subjects aged 18 to 75 years (inclusive, at the time of signing the informed consent form). 2. Disease Diagnosis: Fulfill the 2009 Assessment of SpondyloArthritis International Society (ASAS) classification criteria for axial spondyloarthritis (SpA). Patients must have: onset of symptoms before age 45 and chronic back pain for =3 months; and meet one of the following: a) Sacroliitis on Imaging: Active (acute) inflammation on MRI highly suggestive of sacroiliitis associated with SpA, OR definite radiographic sacroiliitis according to the modified 1984 New York criteria; and at least one other SpA feature. b) HLA-B27 Positivity: Positive for HLA-B27 and at least two other SpA features. SpA features include, but are not limited to: Inflammatory back pain; Arthritis; Enthesitis (heel); Uveitis; Dactylitis; Psoriasis; Crohn's disease or ulcerative colitis; Good response to NSAIDs; Family history of SpA; HLA-B27 positivity; Elevated C-reactive protein (CRP). 3. Informed Consent: Subjects must fully understand the content, purpose of the study, be able to complete the study per protocol, voluntarily participate, and be capable of signing the informed consent form. Inclusion Criteria for Normal Controls: 1. Age Requirement: Male or female subjects aged 18 to 75 years (inclusive, at the time of signing the informed consent form). 2. Health Status: Normal control subjects should have no history of any related diseases such as spondyloarthritis. 3. Informed Consent: Subjects must fully understand the content, objectives, and characteristics of the study, be able to complete the study per protocol, voluntarily participate, and be capable of signing the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Unwillingness to provide informed consent: Patients who decline to participate or are unable to provide voluntary informed consent. 2. Significant dysfunction of major organs: Patients with conditions such as heart failure, abnormal liver function, or renal insufficiency. 3. Concomitant malignancy: Patients with a history of or currently undergoing treatment for malignant tumors. 4. Pregnancy or lactation: Women who are pregnant or breastfeeding at the time of screening.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cervical Rotation;Modified Schober’s Test;Lateral Spinal Flexion;Intermalleolar Distance;Occiput to wall and tragus to wall;accuracy; | — |
Countries
China
Contacts
Public ContactYuling Chen
The Seventh Affiliated Hospital, Sun Yat-sen University
Outcome results
None listed