Pulmonary metastasis of breast cancer
Conditions
Interventions
breast cancer lung metastasis lesion group:None
primary breast cancer lesion group:None
Sponsors
Beijing Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients who underwent surgical resection or biopsy at Beijing Hospital between June 2010 and June 2025, with pathologically confirmed breast cancer and possessing the clinical data required for this study. 2. Availability of complete medical records, including demographic characteristics, clinicopathological features, treatment information, and records of recurrence/metastasis/death. 3. Availability of residual formalin-fixed, paraffin-embedded (FFPE) tissue samples (from the primary lesion or a pulmonary metastatic lesion) obtained after surgery/biopsy.
Exclusion criteria
Exclusion criteria: 1. Tissue samples not meeting the quality standards for molecular analysis (e.g., improper fixation, severe degradation, or insufficient tissue). 2. Incompleteness of key clinical data to the extent that comprehensive analysis is not possible. 3. Coexistence of other active malignancies or non-breast cancer-related pulmonary lesions (applied specifically to the lung metastasis cohort).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| differential expression of TTC17; | — |
Secondary
| Measure | Time frame |
|---|---|
| correlation between TTC17 expression and myeloid immune cell infiltration;correlation between TTC17 expression and clinicopathological parameters;differential expression of genes in the TTC17 downstream pathway; | — |
Countries
China
Contacts
Public ContactGuo Fengzhu
Beijing Hospital
Outcome results
None listed