insomnia disorder
Conditions
Interventions
Sham Stimulation Control Group:Sham stimulation was administered using the Cool?B65 A/P (Active/Placebo) coil of the MagPro R30 transcranial magnetic stimulator.
rTMS Treatment Group (Insomnia Disorder):repetitive Transcranial Magnetic Stimulation
Sponsors
Wuxi Mental Health Center
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.Inclusion criteria for the insomnia disorder group at baseline: 1) Chinese nationality, Han ethnicity, right-handed, both genders eligible, aged 18–60 years with at least primary school education, and written informed consent obtained from the patients; 2) First clinical visit primarily for insomnia symptoms, meeting the DSM-5 diagnostic criteria for insomnia disorder as assessed by the SCID-5; 3) Subjective complaint of sleep disturbance, with a PSQI score > 10; 4) Hamilton Depression Rating Scale (24-item version) score 85; 6) No family history of psychiatric disorders among first-degree relatives.
Exclusion criteria
Exclusion criteria: 1.Exclusion criteria for the insomnia disorder group: 1) Meeting diagnostic criteria for any psychiatric disorder other than insomnia disorder as assessed by the Structured Clinical Interview for DSM-5 (SCID-5); 2) Presence of organic brain disorders or severe, unstable somatic diseases (e.g., cardiac conditions); 3) History of epilepsy, febrile seizures, or coma (with loss of consciousness exceeding 5 minutes); 4) History of alcohol or substance abuse; 5) Contraindications to sleep electroencephalography monitoring; 6) Women who are pregnant or breastfeeding; 7) Wechsler Intelligence Scale score < 70. 2.Exclusion criteria for the healthy control group: 1) Wechsler Intelligence Scale score < 70; 2) Presence of organic brain disorders or severe, unstable somatic diseases (e.g., cardiac conditions); 3) History of epilepsy, febrile seizures, or coma (with loss of consciousness exceeding 5 minutes); 4) History of alcohol or substance abuse; 5) Contraindications to sleep electroencephalography monitoring; 6) Women who are pregnant or breastfeeding.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Glymphatic System Function;Electroencephalography;Change in Pittsburgh Sleep Quality Index Total Score;General demographic information; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton Depression Scale Total Score;Hamilton Anxiety Scale Total Score;Composite Cognitive Score; | — |
Countries
China
Contacts
Public ContactShan Zhangyan
Wuxi Mental Health Center
Outcome results
None listed