Sepsis-associated acute kidney injury
Conditions
Interventions
sepsis without acute kidney injury group:N/A
sepsis with acute kidney injury group:N/A
Sponsors
Fuzhou University Affiliated Provincial Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Meets the internationally recognized diagnostic criteria for sepsis [Sepsis-3 criteria, i.e., infection accompanied by a Sequential Organ Failure Assessment (SOFA) score>=2]; (2) Age 18-80 years; (3) Patients who have not died or been discharged voluntarily within 48 hours of ICU admission; (4) Patient/family has signed the informed consent form; (5) Able to cooperate to complete a one-year follow-up observation;
Exclusion criteria
Exclusion criteria: 1.Aged under 18 years or over 80 years; 2.Complicated with acute kidney injury (AKI), severe liver disease, chronic kidney disease, chronic renal insufficiency, or end-stage renal disease prior to ICU admission; 3.Patients with malignant tumors, rheumatic immune system diseases, hematologic diseases (e.g., leukemia, aplastic anemia, etc.) that may affect the quantity and function of peripheral blood cells, autoimmune diseases, organ transplantation, or splenectomy; 4.Pregnant patients; 5.Patients who have received immunosuppressant therapy or hormone therapy recently (within 3 months); 6.Length of ICU stay less than 48 hours; 7.Known allergy or contraindication to study-related tests; 8.Poor compliance and inability to complete follow-up observations; 9.Other conditions deemed ineligible for enrollment by the investigators;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Natural Killer Cell;Cytokines: PCT, C-reactive protein, IL-6, NT-proBNP, troponin I;T cell subsets(CD3?CD4?CD8);Complete Blood Count;Comprehensive Biochemical Profile;serum Cystatin C;Arterial Blood Gas?Blood Lactic Acid; | — |
Secondary
| Measure | Time frame |
|---|---|
| Onset time of sepsis-associated acute kidney injury;time to recovery of serum creatinine to normal levels;Hospital LOS (Length of Stay),ICU LOS;ICU mortality, mortality at 60?90 and 180 days;Proportion of sepsis-associated AKI progressing to CKD; | — |
Countries
China
Contacts
Public ContactHangwei Feng
Fuzhou University Affiliated Provincial Hospital
Outcome results
None listed