postpartum depression
Conditions
Interventions
NS+ESK group:Immediately after the delivery of the fetus, the parturient received a saline nasal spray, one spray in each nostril. Five minutes later, she was administered 0.2 mg/kg of esketamine intr
DEX+ESK group:Immediately after the fetus was delivered, the parturient received a nasal spray of dexmedetomidine, one spray in each nostril (25 µg per spray), and 5 minutes later, she was administere
Sponsors
Women and Children's Medical Center Affiliated to Guangzhou Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18 - 45 years old; 2. Healthy singleton pregnancy; 3. Gestational age >= 37 weeks; 4. Height: 150 - 180 cm, BMI <= 34 kg/m^2; 5. ASA classification: Grade II; 6. All prenatal screening items for the fetus are normal; 7. The patient agrees to participate in this study and signs the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Had a history of emotional disorders (including depression) before pregnancy; 2. Had communication disorders; 3. Had severe pregnancy complications (such as preeclampsia, HELLP syndrome); 4. Had contraindications for esketamine (such as allergy to esketamine, refractory hypertension, cerebrovascular disease, cardiovascular disease or hyperthyroidism); 5. Had contraindications for Dexmedetomidine (such as allergy to Dexmedetomidine, heart rate < 50 beats per minute, or presence of cardiac conduction or rhythm abnormalities, preoperative systolic blood pressure < 90 mm Hg or diastolic blood pressure < 60 mm Hg); 6. ASA Level III or above
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The positive rate of PPD on the 7th day after the operation; | — |
Secondary
| Measure | Time frame |
|---|---|
| EPDS(Edinburgh Postnatal Depression Scale) score;NRS(Numerical Rating Scale) score;The incidence of dissociation;Insomnia Severity Index(ISI);The time of the first postoperative defecation and flatus expulsion;Complications within 2 days after the operation;Newborn outcome; | — |
Countries
China
Contacts
Public ContactMo Xiaofei
Women and Children's Medical Center Affiliated to Guangzhou Medical University
Outcome results
None listed