Adverse drug reactions during anaesthetic induction: cough induced by sufentanil.Post-anaesthetic complications: postoperative sore throat following tracheal intubation.
Conditions
Interventions
Placebo group:Pseudo-transcutaneous auricular vagus nerve stimulation
Sponsors
Shunde Hospital of Guangzhou University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 18 to 65 scheduled for elective surgery under general anaesthesia with endotracheal intubation; 2. 18 kg/m^2<= BMI <=30 kg/m^2; 3. American Society of Anaesthesiologists (ASA) Class I-III; 4. Subjects voluntarily participated in this trial and signed an informed consent form (ICF).
Exclusion criteria
Exclusion criteria: 1. Take cough suppressants/glucocorticoids 24 hours prior to surgery; 2. Individuals with a history of taVNS treatment or those allergic to any component of the medication; 3. Patients with severe heart, liver, kidney, brain or lung disease,such as NYHA functional class III-IV, Child-Pugh class C, creatinine clearance <30 mL/min, etc. 4. Pregnant or breastfeeding women; 5. Patients with psychiatric disorders (schizophrenia, mania, bipolar disorder, psychosis, etc.), a history of long-term psychiatric medication use, and cognitive impairment; 6. Individuals with ear conditions or skin lesions affecting the placement of the taVNS patch; 7. History of chronic cough, asthma, and chronic obstructive pulmonary disease (COPD); 8. Abnormal vagal tone (such as sick sinus syndrome, atrioventricular block, etc.); 9. Those who do not understand the test method or refuse to undergo testing.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence and Severity of Coughing During Anaesthetic Induction;The incidence and severity of postoperative sore throat; | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse reactions during preoperative transcutaneous vagus nerve stimulation (taVNS) treatment, induction, and postoperative periods;Total dose of postoperative analgesic rescue medication Time of first analgesic rescue request;Haemodynamic fluctuations during anaesthetic induction (mean arterial pressure, heart rate);24 hours post-surgery Visual Analogue Scale (VAS) score;Total dosage of anaesthetic agents administered during general anaesthesia;Blind Method Effectiveness Evaluation;Post-anaesthesia care unit immediate visual analogue scale score;Patient satisfaction; | — |
Countries
China
Contacts
Public ContactWen Jiajun
Shunde Hospital of Guangzhou University of Traditional Chinese Medicine
Outcome results
None listed