Metabolic Dysfunction-Associated Steatotic Liver Disease
Conditions
Interventions
MASLD patient group:no
healthy control group:no
Sponsors
The First Affiliated Hospital of Army Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Healthy Control Group: (1) Aged 18 years or older and under 80 years, with no restriction on gender; (2) No known systemic diseases, including cardiovascular, respiratory, digestive, urinary, endocrine, neurological diseases and other relevant disorders; (3) No history of psychiatric or neurological disorders, including depression, anxiety, schizophrenia, epilepsy and the like; (4) Normal physical examination findings, with blood pressure, heart rate, body mass index (BMI) and other parameters within the normal range; (5) Normal laboratory test results, with complete blood count, biochemistry panel (liver and renal function, electrolytes, blood glucose, blood lipids), urine routine and other indices all within the reference ranges; (6) Unremarkable imaging or special examination results (if required for the study), such as cerebral imaging, electrocardiogram and other relevant tests; (7) Able to comprehend the study protocol and voluntarily provide written informed consent. 2. MASLD Patient Group: (1) Aged 18 years or older and under 80 years, with no restriction on gender; (2) Diagnosed with metabolic dysfunction-associated steatotic liver disease; (3) Voluntarily sign the informed consent form and cooperate with the completion of study-related tests.
Exclusion criteria
Exclusion criteria: 1. Healthy Control Group: (1) Recent history of acute illness or infection (within the past 4 weeks); (2) History of chronic medication use: long-term administration of drugs (e.g., antidepressants, hormonal agents, immunosuppressants, etc.); (3) History of alcohol consumption, drug abuse or substance misuse; (4) Pregnant, lactating, or with a plan for pregnancy; (5) Individuals unable to complete psychological scale assessments. 2. MASLD Patient Group: (1) Non-MASLD-related liver diseases: such as viral hepatitis, alcoholic liver disease, autoimmune liver disease, inherited metabolic liver disease, and drug-induced liver injury; (2) Definite central nervous system diseases: such as ischemic stroke, hemorrhagic stroke, Alzheimer's disease, schizophrenia, and other severe mental illnesses; (3) Factors affecting MRI examination: presence of metal implants in the body or claustrophobia; (4) Severe systemic diseases, including chronic heart failure, chronic obstructive pulmonary disease (COPD), chronic kidney disease (CKD), malignant tumors, and others; (5) Factors interfering with brain structure or function: history of traumatic brain injury, intracranial tumor, hydrocephalus, or having undergone brain surgery or radiotherapy within the past 6 months; (6) Females who are pregnant or lactating; (7) Individuals unable to complete psychological scale assessments.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 7T Cranial Magnetic Resonance Imaging (MRI) Data; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hepatic Fibrosis and Inflammatory Markers;Liver and Renal Function, Blood Lipids, Blood Glucose;Liver Fat Content Percentage;Complete Blood Count (CBC);Scores of the Self-Rating Anxiety Scale (SAS), the Self-Rating Depression Scale (SDS), the Montreal Cognitive Assessment (MoCA), and the Pittsburgh Sleep Quality Index (PSQI);Body Composition Analysis Data; | — |
Countries
China
Contacts
Public ContactChai Jin
The First Affiliated Hospital of Army Medical University
Outcome results
None listed