Mechanisms and Interventions for Low Aerobic Threshold and Skeletal Muscle Dysfunction in COPD Patients

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2600119298

Enrollment

Unknown

Registered

2026-02-25

Start date

2026-03-01

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic obstructive pulmonary disease (COPD)

Interventions

Aerobic Training Group:8 weeks of aerobic training (intensity at individual anaerobic threshold, mode: jogging, 30 minutes per session, 3-5 times per week)

Respiratory Muscle Training Group:8 weeks of respiratory muscle training (using tricolor ball breathing trainer, 10 minutes per session, 3-5 times per week)

Control Group:No intervention

Eligibility

Sex/Gender

All

Age

35 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Complies with COPD diagnosis; 2. After tracheal relaxants, (FEV1/FVC) 90%.

Exclusion criteria

Exclusion criteria: 1. Treatment with sympathomimetic drugs (such as theophylline); 2. Primary pulmonary arterial hypertension; 3. Heart failure with decreased EF values (left ventricular ejection fraction5cm); 7. Previously suffered from tension pneumothorax; 8. Uncontrolled hypertension; 9. Unstable angina pectoris.

Design outcomes

Primary

Measure	Time frame
Anaerobic Threshold Power;Oxygen Uptake;Heart Rate;	—

Secondary

Measure	Time frame
Peak Power Output;Peak Oxygen Uptake;Peak Heart Rate;Heart Rate Decline at 1 Minute Post-Exercise;Heart Rate Response Index;Twelve-Lead Electrocardiogram;Blood Pressure;Oxygen Saturation;Subjective Symptoms;	—

Countries

China

Contacts

Public ContactChen Anliang

Nanjing First Hospital

anliangchen2011@163.com+86 189 5167 0159

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Mar 14, 2026