Hirschsprung’s disease (HSCR) is a congenital malformation of the digestive tract characterized clinically by constipation and histologically by the absence of ganglion cells in the affected bowel segment. It is one of the more common gastrointestinal developmental anomalies, occurring in roughly 1 in 5 000 live births, with a marked male predominance (male-to-female ratio ˜ 4:1). The disorder sho
Conditions
Interventions
Primary-surgery group:None
Redo-surgery group:None
Sponsors
Tongji Hospital, Tongji Medical College ,Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Delayed passage of meconium after birth; 2. No response to conservative treatment; 3. Persistent or recurrent constipation, abdominal distension, enterocolitis, or fecal soiling following previous Hirschsprung surgery; 4. Parental consent to the proposed operative plan.
Exclusion criteria
Exclusion criteria: 1. Anastomotic leakage after the initial pull-through; 2. Previous ileostomy or colostomy; 3. Contra-indications to surgery, e.g. severe malnutrition or immunodeficiency rendering the child unfit for operation; 4. Parental refusal of surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| BMIZ score;intraoperative blood loss;time to first postoperative bowel movement;;postoperative complications;length of postoperative hospital stay; | — |
Countries
China
Contacts
Public ContactYu Donghai
Tongji Hospital, Tongji Medical College ,Huazhong University of Science and Technology
Outcome results
None listed