Subarachnoid hemorrhage
Conditions
Interventions
Unruptured intracranial aneurysm group:None
Sponsors
First Hospital of Jilin University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Age between 18 and 60 years, with no restriction on gender; 2. Definite diagnosis of intracranial aneurysm confirmed by MRA, CTA, or DSA; 3. Patients with aneurysmal subarachnoid hemorrhage must have radiological evidence of hemorrhage on head CT, and the interval between hemorrhage onset and blood sample collection must not exceed 3 days; 4. Scheduled to undergo neurointerventional treatment of intracranial aneurysm under general anesthesia; 5. Willing to comply with the study protocol and data collection procedures; 6. Able to understand and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Pre-onset modified Rankin Scale (mRS) score >= 2 for hemorrhagic patients, or preoperative mRS score >= 2 for non-hemorrhagic patients; 2. Presence of other neurological disorders such as Parkinson’s disease, Alzheimer’s disease, cerebral infarction, brain tumors, or epilepsy; 3. Presence of other systemic diseases such as diabetes, coronary heart disease, cancer, infections, hematological disorders, or severe metabolic diseases that may significantly affect the evaluation of blood EVs; 4. History of severe hepatic or renal dysfunction (ALT > 3 × upper limit of normal; creatinine > 225 µmol/L); 5. Unable to tolerate anesthesia or anticoagulant therapy, or with coagulation disorders; 6. History of severe reactions to contrast agents; 7. Pregnancy; 8. Participation in other clinical trials with follow-up not yet completed.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum proteomics;Serum metabolomics;Extracellular vesicles proteomics; | — |
Countries
China
Contacts
Public ContactHonglei Wang
First Hospital of Jilin University
Outcome results
None listed