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Early diagnosis of post-operative cholangitis in biliary atresia based on heart rate variability

Early diagnosis of post-operative cholangitis in biliary atresia based on heart rate variability

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600119277
Enrollment
Unknown
Registered
2026-02-25
Start date
2026-03-01
Completion date
Unknown
Last updated
2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Biliary Atresia

Interventions

Biliary atresia observation group:None

Sponsors

Department of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Due to biliary atresia, the patient underwent surgical exploration in the pediatric surgery department of our hospital. During the operation, biliary atresia was diagnosed and Kasai surgery was performed. The control group included healthy children of similar age, children with jaundice not caused by biliary atresia, and children who underwent surgery for non-inflammatory reasons. 2. Willing to cooperate in completing the dynamic electrocardiogram examination and generating a heart rate variability analysis report. 3. Developed cholangitis after surgery and was hospitalized in the pediatric surgery department of our hospital for treatment. 4. Complete medical records and regular follow-up after surgery.

Exclusion criteria

Exclusion criteria: 1. The medical records are incomplete; 2. Children with arrhythmia need to be excluded; 3. There are other congenital biliary tract lesions and malformations, and cholangitis that does not occur after Kasai surgery; 4. Follow-up was lost after the surgery.

Design outcomes

Primary

MeasureTime frame
Standard deviation of all normal sinus rhythm intervals;Standard deviation of the averages of normal-to-normal intervals ,SDANN;Root mean square of successive differences, RMSSD;Percentage of normal-to-normal intervals differing by more than 50 ms,pNN50;Total Power ;Very Low Frequency;Low Frequency ;High Frequency ;Ratio of low-frequency power to high-frequency power;

Secondary

MeasureTime frame
White Blood Cell;Neutrophil;C-Reactive Protein;

Countries

China

Contacts

Public ContactJixin Yang

Department of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

yangjixin0910@126.com+86 27 8366 2711

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Mar 14, 2026