Primary hypertension
Conditions
Interventions
Intervention Group:Percutaneous ear vagus nerve stimulation
Sponsors
The First Affiliated Hospital of Henan Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Male or female patients with hypertension aged between 18 and 70 years. 2. Meet the diagnostic criteria for essential hypertension as specified in Chinese Guidelines for the Prevention and Treatment of Hypertension (Revised Edition 2024). 3. Not taking medication or currently using monotherapy or combination therapy, and the medication regimen cannot be adjusted during the trial period. 4. Voluntarily participate in this study and sign an informed consent form. 5. Able to understand and comply with all requirements during the research process, including treatment, follow-up, and examinations.
Exclusion criteria
Exclusion criteria: 1. Confirmed secondary hypertension (such as renal vascular hypertension, primary aldosteronism, and other hypertension with clear causes). 2. Combined with serious heart diseases (such as acute myocardial infarction, heart failure, severe arrhythmia, etc.), cerebrovascular diseases (such as acute stroke, frequent transient ischemic attacks, etc.), liver and kidney dysfunction, malignant tumors, and other serious systemic diseases. 3. Having mental or cognitive impairments, unable to cooperate with research or understand the content of informed consent forms. 4. Having a history of ear disease or ear surgery may affect the implementation or safety of percutaneous vagus nerve stimulation therapy. 5. Pregnant or lactating women. 6. Other researchers believe that participants who are not suitable to participate in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 24-hour average systolic/diastolic blood pressure, average heart rate, daytime average systolic/diastolic blood pressure, nighttime average systolic/diastolic blood pressure;Circadian blood pressure decline rate?Change in blood pressure load value?Change in morning blood pressure peak?24-hour, daytime/nighttime blood pressure standard deviation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Emotional indicators;Sleep quality; | — |
Countries
China
Contacts
Public ContactXiaohong Kang/Chen Zhigang
The First Affiliated Hospital of Henan Medical University
Outcome results
None listed