Cervical cancer
Conditions
Interventions
Gold Standard:Histopathological results from colposcopy and subsequent excisional therapy serve as the gold standard for the diagnosis of cervical cancer and precancerous lesions
Index test:Multi-omics biomarker panel
Sponsors
China Welfare association international peace Maternal and Child Health hospital
Eligibility
Sex/Gender
Female
Age
25 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Females aged 25 years or older, with a history of sexual activity and not currently pregnant; 2.Intact cervix; 3.No history of CIN treatment within the past 6 months; 4.No history of malignant tumors; 5.Able and willing to provide all three types of tissue samples in accordance with the study protocol, ensuring cervical tissue sample >=10mg, cervical exfoliated cell sample >=3ml, and peripheral blood sample >=5ml. 6.Voluntarily participate in this study, be able to understand the study procedures, and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Pregnant or lactating women; 2.Prior history of cancer in any organ; 3.Have severe uncontrolled systemic disease (e.g., heart, lung, liver, or kidney failure; active autoimmune disease). 4.Incomplete medical record information (including but not limited to sex, age, clinicopathological diagnosis, and other demographic data) or incomplete sample identification that prevents accurate matching. 5.Prior history of CIN2, CIN3, or cervical carcinoma, along with any associated treatment (e.g., surgery); 6.Withdrew prematurely from the study before reaching the endpoint; 7.Exclusion due to: insufficient sample volume, poor sample quality, or technical failure in assay data generation for any sample type;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Multi-omics biomarker panel; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pathology report of cervical biopsy after colposcopy; | — |
Countries
China
Contacts
Public ContactYudong Wang
China Welfare association international peace Maternal and Child Health hospital
Outcome results
None listed