Low back pain associated with lumbar disc herniation
Conditions
Interventions
Low back pain with lumbar disc herniation group:None
Sponsors
Fifth Affiliated Hospital, Sun Yat-Sen University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Voluntarily signs the written informed consent form. 2.Aged between 18 and 70 years, any gender. 3.Able to independently complete pain assessment using the Numerical Rating Scale (NRS) and functional assessment using the Oswestry Disability Index (ODI). 4.NRS pain score >= 4, indicating moderate or higher pain impact. 5.Diagnosed with lumbar disc herniation (LDH) according to the "Chinese Guidelines for the Diagnosis and Treatment of Lumbar Disc Herniation (latest edition)" and imaging examinations (MRI or CT), with imaging findings consistent with clinical symptoms/signs (e.g., sciatica, radiating leg pain, positive straight-leg raise test). The condition is unresponsive to standard conservative treatment, meets clinical surgical indications, and the patient is scheduled for lumbar disc discectomy.
Exclusion criteria
Exclusion criteria: 1.Presence of other severe spinal diseases (e.g., spinal tumors, spinal tuberculosis, spinal fractures, ankylosing spondylitis, etc.). 2.Presence of severe cardiac, hepatic, renal, or hematologic diseases, or metabolic disorders (e.g., diabetes, thyroid dysfunction) that may significantly affect metabolomic analysis results. 3.Recent (within the past month) use of systemic glucocorticoids, immunosuppressants, or other medications that may alter metabolite profiles. 4.Pregnant or breastfeeding women, or women planning pregnancy in the near future. 5.Severe psychiatric or cognitive disorders that prevent compliance with follow-up visits and questionnaire assessments. 6.Currently participating in other clinical trials, or recent participation that may interfere with study outcomes. 7.Any other conditions deemed unsuitable for inclusion by the investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain score (NRS);3-Hydroxyisobutyric acid (3-HIB) level; | — |
Secondary
| Measure | Time frame |
|---|---|
| Functional score (ODI);Inflammatory cytokine levels; | — |
Countries
China
Contacts
Public ContactZhan Hongrui
Fifth Affiliated Hospital, Sun Yat-Sen University
Outcome results
None listed