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?TSPO Regulation of Mitochondria-Associated Endoplasmic Reticulum Membrane Structure and Function in Macrophages Mediates Inflammation during Myocardial Infarction: A Study on the Role and Mechanism

?TSPO Regulation of Mitochondria-Associated Endoplasmic Reticulum Membrane Structure and Function in Macrophages Mediates Inflammation during Myocardial Infarction: A Study on the Role and Mechanism

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600119254
Enrollment
Unknown
Registered
2026-02-25
Start date
2026-02-25
Completion date
Unknown
Last updated
2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ischemic Cardiomyopathy?

Interventions

Non-infarcted Zone of Ischemic Cardiomyopathy:None
Infarcted Zone of Ischemic Cardiomyopathy:None

Sponsors

NanJing First Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1.Age 18 or older; 2.Pathological diagnosis after heart transplant surgery:? ?Ischemic cardiomyopathy group:? Meets the diagnostic criteria for coronary artery disease-induced myocardial ischemia, infarction, and heart failure. ?Dilated cardiomyopathy group:? Meets the diagnostic criteria for primary dilated cardiomyopathy, with no significant stenosis of the coronary arteries. 3.The heart tissue specimen is preserved intact and can be used for pathological examination; 4.Complete clinical documentation, including medical history, operative records, and pathology reports.

Exclusion criteria

Exclusion criteria: 1.Combined with other structural heart diseases (such as valvular heart disease, congenital heart disease)?; 2.Combined with active infection, tumor, or immune system disease; 3.Incomplete clinical or pathological data; 4.The sample quality does not meet the testing requirements.

Design outcomes

Primary

MeasureTime frame
TSPO expression levels;Inflammatory cell infiltration;

Countries

China

Contacts

Public ContactGanyi Chen

NanJing First Hospital

cgygary@163.com+86 25 5227 1370

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Mar 14, 2026