Hypotension that occurs during the anesthesia induction period
Conditions
Interventions
Group G:Etomidate 0.15 mg/kg
Group D:Remimazolam 0.1 mg/kg
Group B:Cyclopofol 0.4mg/kg
Group E:Cyclopofol 0.2mg/kg + Remimazolam 0.05 mg/kg
Group A:Cyclopofol 0.2mg/kg + esketamine 0.2mg/kg
Group F:Propofol 1 mg/kg
Group C:Remimazolam 0.05mg/kg + S-ketamine 0.2mg/kg
Sponsors
NanJing First Hospital
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Elective cardiac surgery under cardiopulmonary bypass, median sternotomy, and double-lung ventilation. 2.ender is not limited, age (40-80 years old). 3.Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Secondary and emergency cardiac surgeries; 2.revious history of cerebral infarction/cerebral hemorrhage, with preoperative cognitive dysfunction; 3.Preoperative ultrasound examination revealed stenosis in the carotid artery; 4.Severe liver and kidney dysfunction, respiratory system disorders (COPD, OSAS, asthma, having had pneumonia or lung infection in the past 30 days, having undergone lung resection surgery before); 5.Before anesthesia induction, continuous use of vasoactive drugs was required to maintain blood pressure;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ncidence of hypotension during the induction period;Total consumption of vasoactive drugs during the induction period; | — |
Secondary
| Measure | Time frame |
|---|---|
| The effect of depth control of anesthesia during the induction period;Induction period cerebral perfusion indicators - Carotid artery diameter (CaD, mm) - Carotid artery velocity-time integral (cVTI, cm) - Carotid artery corrected flow time (ccFT, ms) - Carotid artery f;The average arterial pressure (MAP) values (in mmHg) and heart rate (HR) values (in beats per minute) at each time point (T0: baseline; T1 - T10: 1 - 10 minutes after induction).;The incidence of perioperative cognitive dysfunction (POCD);The incidence of acute kidney injury (AKI);Intubation Conditions; | — |
Countries
China
Contacts
Public ContactShi Hongwei
NanJing First Hospital
Outcome results
None listed