Prediabetes
Conditions
Interventions
Prediabetes usual care group:Nutrition and physical activity (lifestyle) education
Traditional lifestyle intervention group:Nutrition and physical activity intervention by dietitians
Low-glycemic-index fruit preload-based lifestyle intervention group:Based on the traditional lifestyle intervention, consume 100 grams of fruits 30 minutes before lunch and 30 minutes before dinner
Sponsors
China Agricultural University
Eligibility
Sex/Gender
All
Age
10 Years to 19 Years
Inclusion criteria
Inclusion criteria: 1. Males and females 2. Aged 10–19 years 3. Diagnosed with prediabetes in a hospital setting (i.e., glycated hemoglobin >=5.6% but <6.5%) 4. Overweight or obese, based on the gender- and age-specific BMI reference cut-off points for screening overweight and obesity in school-age children and adolescents according to "WS/T 586—2018 Screening for Overweight and Obesity in School-Age Children and Adolescents" 5. Negative for type 1 diabetes–related antibodies 6. Day students who eat breakfast and dinner at home
Exclusion criteria
Exclusion criteria: 1. There are diseases such as hypercortisolism, growth hormone tumor, glucagonoma, etc. 2. Hypertension grade 3 3. Within the past 3 months, any hypoglycemic measures have been taken, such as health supplements or traditional Chinese medicine. 4. Within 6 months, weight loss of more than 5 kg has occurred or weight loss is ongoing, or other methods of weight loss are planned, such as bariatric surgery. 5. Within the past 3 months, have taken known drugs that may affect glucose tolerance (such as thiazide diuretics, glucocorticoids, spironolactone, etc.) or have diseases that affect the main outcome and its measurement indicators, such as anemia, hemoglobin-related diseases, etc. 6. Have severe mental disorders, such as schizophrenia, bipolar disorder, autism/spectrum disorder, etc. 7. Have other serious diseases, such as severe dyspepsia, liver cirrhosis, pancreatitis, inflammatory bowel disease, chronic kidney disease, cancer, heart failure, etc.; have infectious diseases, such as hepatitis B or AIDS; have chronic respiratory, neurological, musculoskeletal or other diseases that cannot comply with the trial protocol or have risks in complying with the trial protocol (such as moderate-intensity physical activity) 8. Have undergone surgery within 3 months or are still in the postoperative recovery period 9. Have eating disorders or binge eating disorder or anorexia nervosa 10. Are participating in other clinical trials 11. Are non-day students, have an overly busy academic schedule, or the guardian cannot cooperate, etc., unable to follow the research protocol or have risks in following the protocol (such as moderate-intensity physical activity)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Prediabetes remission; | — |
Secondary
| Measure | Time frame |
|---|---|
| Satiety;Body weight;Waist circumference;Body fat percentage; | — |
Countries
China
Contacts
Public ContactRuixin Zhu
China Agricultural University
Outcome results
None listed