Patients with disorders of consciousness 28 days to 1 year after brain injury
Conditions
Interventions
real TI+real MNS group:Transcranial Temporal Interference Stimulation combined with Median Nerve Stimulation
sham TI+real MNS group:Transcranial Temporal Interference Stimulation
Sponsors
Xuzhou Rehabilitation Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 18-80 years, diagnosed with Coma, Vegetative State (VS), or Minimally Conscious State (MCS) according to the Coma Recovery Scale-Revised (CRS-R) based on multiple CRS-R assessments, with a disease duration of =28 days and =12 months; 2. Etiology includes traumatic brain injury, cerebrovascular accident, or hypoxic-ischemic encephalopathy; 3. Stable clinical condition: vital signs stable without the need for high-dose sedative or analgesic agents; 4. No history of alcohol abuse, substance abuse, or psychiatric disorders; 5. No administration of sedatives or muscle relaxants within 24 hours prior to behavioral assessments and MRI examinations; 6. Absence of severe comorbidities: no significant structural damage to bilateral brain stem, thalamus, or spinal cord;no severe cardiac, pulmonary, hepatic, or renal failure;cord;no severe cardiac, pulmonary, hepatic, or renal failure; 7. Informed consent obtained: written informed consent provided by legal guardians.
Exclusion criteria
Exclusion criteria: 1. Unstable vital signs; 2. Intracranial retention of metallic objects; 3. History of epilepsy or psychiatric disorders; 4.Presence of severe functional impairment in critical organs such as the heart, liver, or kidneys; 5. Administration of sedatives or neuromuscular blocking agents within 24 hours prior to behavioral assessments or MRI examinations.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| coma recovery scale-revised; | — |
Secondary
| Measure | Time frame |
|---|---|
| Electroencephalograph;near-infrareed spectroscopy;functional Magnetic Resonance Imaging; | — |
Countries
China
Contacts
Public ContactJiaojiao Chen
Xuzhou Rehabilitation Hospital
Outcome results
None listed