Research on Transcranial Ultrasound Stimulation for Improving Mild Cognitive Impairment in the Elderly

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2600119222

Enrollment

Unknown

Registered

2026-02-24

Start date

2026-03-01

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mild cognitive impairment

Interventions

Test group:Transcranial Ultrasound Stimulation

Control group:Transcranial Ultrasound Sham Stimulation

Eligibility

Sex/Gender

All

Age

55 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Age: 55–80 years old; 2. The patient or family member provides a memory complaint. 3. Objective memory impairment (<1–1.5 SD); 4. Montreal Cognitive Assessment score <= 26; 5. Clinical Dementia Rating Scale score: 0.5; 6. Ability to perform normal activities of daily living.

Exclusion criteria

Exclusion criteria: 1. Suffering from major systemic diseases that may affect cognitive function (such as heart failure, liver or kidney failure, etc.); 2. Suffering from severe mental illness (such as bipolar disorder, psychosis) or a history of epileptic seizures; 3. History of stroke and other neurodegenerative diseases (such as Parkinson's disease); 4. Contraindications for transcranial ultrasound: Severe cardiac, hepatic, or renal insufficiency; bleeding disorders or individuals with a tendency to bleed; acute infectious diseases; active pulmonary tuberculosis; malignant tumors; thrombotic lesions (in the area of electrical stimulation); local skin lesions; pregnancy; and individuals unable to tolerate electrical current. Use with caution in patients with thrombophlebitis or impaired skin sensory perception. 5. History of alcohol or drug abuse; 6. Patients may be on stable doses of cholinesterase inhibitors and/or memantine for at least 4 weeks prior to screening, with no dose adjustments required during the study period.

Design outcomes

Primary

Measure	Time frame
Montreal Cognitive Assessment Scale;	—

Secondary

Measure	Time frame
Functional Near-Infrared Spectroscopy;Functional Activities Questionnaire;Auditory Vocabulary Learning Test;Electroencephalogram;	—

Countries

China

Contacts

Public ContactMao Yurong

The Seventh Affiliated Hospital Sun Yat-sen University

maoyr@mail.sysu.edu.cn+86 755 81206511

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Mar 14, 2026