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A retrospective study on the effects of different doses of remimazolam tosylate combined with sevoflurane on postoperative sleep disorders in patients undergoing elective surgeries

A retrospective study on the effects of different doses of remimazolam tosylate combined with sevoflurane on postoperative sleep disorders in patients undergoing elective surgeries

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600119221
Enrollment
Unknown
Registered
2026-02-24
Start date
2026-02-24
Completion date
Unknown
Last updated
2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative sleep disturbance

Interventions

Postoperative sleep disorder observation group:None

Sponsors

Sun Yat-sen Memorial Hospital of Sun Yat-sen University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Patients aged 18 to 80 years undergoing elective surgery under general anesthesia; 2. ASA grades I-III, with surgery anesthesia duration exceeding 2 hours; 3. Anesthesia maintenance medications include remifentanil combined with sevoflurane for general anesthesia or sevoflurane alone for general anesthesia; 4. Follow-up data on postoperative sleep, mood, and quality of postoperative recovery are available.

Exclusion criteria

Exclusion criteria: 1. History of allergy to benzodiazepines; 2. Previous history of myasthenia gravis, dementia, schizophrenia, severe depression; 3. The patient's general condition is poor, and they have a history of serious diseases such as cardiovascular system, respiratory system, liver and kidney system, central nervous system, and blood system; it is likely that they cannot survive for more than 3 months; 4. Alcoholics or drug addicts; 5. Preoperative use of sedative drugs, antidepressants; 6. Preoperative AIS baseline score >= 6 points. 7. During anesthesia maintenance, other intravenous general anesthetic drugs such as propofol/cyclopropane/etomidate are continuously pumped, or during the perioperative period, adjuvant drugs such as remifentanil, midazolam, nalbuphine, dezocine, noran are used; 8. Main data such as postoperative sleep assessment are missing.

Design outcomes

Primary

MeasureTime frame
Insomnia score;Postoperative insomnia rate;

Secondary

MeasureTime frame
Postoperative delirium;Postoperative recovery quality;Sleep quality score;Postoperative cognitive function;Anxiety and Depression Status Scores;Postoperative recovery status;Postoperative pain;

Countries

China

Contacts

Public ContactYujuan Li

Sun Yat-sen Memorial Hospital of Sun Yat-sen University

yujuan_04@aliyun.com+86 20 8133 2060

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Mar 14, 2026