Periprosthetic bone resorption
Conditions
Interventions
Observation group of periprosthetic bone resorption:None
Sponsors
The First Affiliated Hospital of Dalian Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 60-80 years, with a Kellgren-Lawrence grade >= III and the presence of synovitis; 2. Having received NSAID treatment for at least one week prior to surgery.
Exclusion criteria
Exclusion criteria: 1. The affected knee has other diseases besides osteoarthritis, such as infectious knee arthritis, etc. 2. Severe internal medical conditions, such as serious organic diseases in various systems like the liver, kidneys, heart, etc., and serious primary diseases in the hematopoietic system or those in the acute stage.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cell activity, specific protein expression, interaction between synovium and wear particles, interaction between synovium and osteoclasts; | — |
Secondary
| Measure | Time frame |
|---|---|
| The expression levels of cytokine factors and factors related to bone resorption; | — |
Countries
China
Contacts
Public ContactHongjing Li
The First Affiliated Hospital of Dalian Medical University
Outcome results
None listed