Severely infected
Conditions
Interventions
The group with normal liver function and the group with normal kidney function:None
Renal insufficiency combined with CRRT in the group with normal liver function:None
In the group with normal liver function, renal insufficiency is not combined with CRRT group.:None
The group with normal liver function and the group with hyperrenal disfunction:None
The group of liver insufficiency and the group with normal kidney function:None
Renal insufficiency combined with CRRT group in the liver failure group:None
In the liver failure group, renal insufficiency is not combined with CRRT group.:None
Hypernephrophy group in the hepatic insufficiency group:None
Sponsors
Xiangya Hospital, Central South University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. The age of hospitalisation in ICU is >=18 years old; 2. It is expected to stay in the ICU for at least 7 days; 3. Receive antibacterial drug treatment (oral or intravenous) to be studied in the 14th day before entering the ICU; 4. Patients who need to continue the above drugs for 2-14 days due to presumed or confirmed infection; 5. Patients who already have blood drug concentration data of antibacterial drugs; 6. Participate voluntarily and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Pregnant and/or lactating patients; 2. Die within 3 days after being discharged from the ICU or entering the group; 3. Drug taboos; 4. Oppose to participate in research. The patient's complications and kidney clearance rate do not constitute the exclusion criteria.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Antibacterial drug PK/PD standard rate;Clinical outcome;30-day all-cause mortality rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Effectiveness evaluation (body temperature, oxygenation index, inflammation index, etc.);Types of adverse reactions;Cause and effect of adverse reactions;Grading of adverse reactions; | — |
Countries
China
Contacts
Public ContactDu Jie
Xiangya Hospital, Central South University
Outcome results
None listed