severe/critical infections
Conditions
Interventions
Infectiology Group:None
Sponsors
Hunan Provincial People's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients clinically diagnosed with severe or critical infections of unidentified etiology, including:a. Sepsis or septic shock (with no response to empirical anti-infective therapy after 72 hours and negative conventional cultures);b. Central nervous system infections (with negative routine test results);c. Severe pneumonia (especially in immunocompromised hosts or cases with rapid clinical deterioration). 2. Patients who develop infections while on long-term immunosuppressive therapy. 3. Patients suspected of being infected with special, rare, or emerging pathogens.
Exclusion criteria
Exclusion criteria: 1. Patients in terminal stage or with a life expectancy of less than 24 hours; 2. Patients in whom a clear non-infectious etiology can fully explain all symptoms; 3. Patients with contraindications to specimen collection; 4. Pregnant or postpartum women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The median time (in hours) for a definitive etiological diagnosis; | — |
Secondary
| Measure | Time frame |
|---|---|
| 28-day all-cause mortality rate;The incremental detection rate of traditional negative cases;The rate of adjusting anti-infection treatment based on sequencing results;72-hour clinical response rate;Length of stay in the ICU;Total length of hospital stay; | — |
Countries
China
Contacts
Public ContactXiquan Yan
Hunan Provincial People's Hospital
Outcome results
None listed