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A Randomized, Double-Blind, Placebo-Controlled Study on the Effects of Lactobacillus Plantarum on Gut Microbiota in People Exposed to Noise

A Randomized, Double-Blind, Placebo-Controlled Study on the Effects of Lactobacillus Plantarum on Gut Microbiota in People Exposed to Noise

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600119213
Enrollment
Unknown
Registered
2026-02-24
Start date
2026-03-01
Completion date
Unknown
Last updated
2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Control:Placebo group
Intervention group:Lactobacillus plantarum powder

Sponsors

The First Affiliated Hospital of Harbin Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Age 18–60 years, current factory employee; 2. Daily noise exposure intensity =80 dB, lasting =4 hours; 3. No history of antibiotic or probiotic intake within the past month; 4. Agree to cooperate with sample collection and sign informed consent form.

Exclusion criteria

Exclusion criteria: 1. Underlying intestinal diseases (such as IBD, irritable bowel syndrome, etc.) or other chronic serious diseases; 2. Currently pregnant or breastfeeding; 3. Excessive use of lactic acid bacteria preparations or maltodextrin.

Design outcomes

Primary

MeasureTime frame
abundance of beneficial bacteria;—

Secondary

MeasureTime frame
Plasma inflammatory cytokines;Clinical symptoms (sleep, fatigue, gastrointestinal discomfort);Short-chain fatty acid (SCFA) levels;—

Countries

China

Contacts

Public ContactYongTai Gong

The First Affiliated Hospital of Harbin Medical University

gongth@126.com+86 159 4518 1294

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Mar 14, 2026