None
Conditions
Interventions
The low-dose esketamine group (ED group):During the operation, 2.5 mg/ml low-dose esketamine (0.15 mg·kg-1·h-1) was pumped at a rate of 0.06 ml·kg-1·h-1 until the end of the surgery.
The medium-dose esketamine group (Group E):During the operation, 5 mg/ml of the medium-dose esketamine (0.3 mg·kg-1·h-1) was pumped at a rate of 0.06 ml·kg-1·h-1 until the end of the surgery.
Sodium chloride solution group (Group C):During the operation, normal saline was pumped at a rate of 0.06 ml·kg-1·h-1 until the end of the operation.
Sponsors
Nanjing First Hospital
Eligibility
Sex/Gender
All
Age
45 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age: 45 - 75 years old; 2. BMI: 18 - 28 kg/m^2; 3. ASA classification: Grade II - III; NYHA classification: Grade I - III; EF >= 45%; 4. Scheduled for valve replacement surgery under cardiopulmonary bypass.
Exclusion criteria
Exclusion criteria: 1. Patients who have undergone a second heart surgery; 2. Patients with a PSQI score greater than 6 and a MMSE score less than 24 (illiterate < 17, primary school education < 20, junior high school or above < 24) who had sleep disorders and cognitive dysfunction before the surgery; 3. Patients who took sleep aid and melatonin-like drugs before the surgery; 4. Patients with previous neurological or mental disorders, drug abuse, or taking psychotropic drugs; 5. Patients with significantly elevated infection indicators before the surgery; 6. Patients who cannot communicate normally; 7. Patients with severe liver or kidney dysfunction, or severe respiratory diseases; 8. Patients with contraindications for using esketamine; 9. Patients who refused to participate in the study.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Postoperative cognitive function;Postoperative delirium;Postoperative anxiety;Postoperative pain; | — |
Primary
| Measure | Time frame |
|---|---|
| Postoperative sleep;Postoperative sleep rhythm; | — |
Countries
China
Contacts
Public ContactShi Hongwei
Nanjing Medical University Affiliated Nanjing Hospital (Nanjing City First Hospital)
Outcome results
None listed