None
Conditions
Interventions
Opioid-free group:Anesthesia induction: Dexmedetomidine 0.5 µg/kg (10 minutes), Esketamine 0.25 mg/kg
Anesthesia maintenance: Dexmedetomidine 0.5 µg/kg/h, Esketamine 0.125 mg/kg/h
Conventional opioids group:Anesthesia induction: Sufentanil 0.4 µg/kg
Anesthesia maintenance: Remifentanil 0.2 µg/kg/min
Low opioids group:Anesthesia induction: Dexmedetomidine 0.5 µg/kg (10 minutes), Sufentanil 0.2 µg/kg
Anesthesia maintenance: Dexmedetomidine 0.5 µg/kg/h, Remifentanil 0.1 µg/kg/min
Sponsors
Meizhou People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Elective surgery under general anesthesia; 2. mFI above 0.25, indicating frailty; 3. Abdominal surgery; 4. No clear surgical contraindications; 5. Conscious and alert.
Exclusion criteria
Exclusion criteria: 1. High risk of elevated blood pressure or intracranial pressure; 2. Patients with poorly controlled or untreated hypertension, resting systolic/diastolic blood pressure exceeding 180/100 mmHg; 3. Pregnancy; 4. Untreated or inadequately treated hyperthyroidism; 5. Severe bleeding tendency; 6. Incomplete case data, mFI missing items = 1; 7. History of allergy to anesthetic drugs involved in this study; 8. Abnormal mental state; 9. Postoperative transfer to ICU; 10. Long-term preoperative use of high-dose analgesics; 11. Refusal to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS score 24 hours after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate;Pittsburgh Sleep Quality Index Score;blood pressure;Self-Rating Anxiety Scale Score;Mini-Mental State Examination Scale Score; | — |
Countries
China
Contacts
Public ContactQiu Xianwei
Meizhou People's Hospital
Outcome results
None listed