Type 2 diabetes, male hypogonadism, erectile dysfunction
Conditions
Interventions
T2DM without MH group:None
Control group:None
T2DM with MH group:None
Sponsors
Southern Medical University Southern Hospital
Eligibility
Sex/Gender
Male
Age
30 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.Voluntary signing of the informed consent form; 2.Age >=30 and <60 years; 3.Gender: Male; 4.According to the "Chinese Guidelines for the Prevention and Treatment of Diabetes (2024 Edition)," patients with T2DM were diagnosed as having type 2 diabetes; 5.The serum calculated free testosterone of MH patients is <0.3 nmol/L, and upon retesting after at least one week, the serum calculated free testosterone remains <0.3 nmol/L. 6.Patients who voluntarily participate in this study, can understand and sign a written informed consent form;
Exclusion criteria
Exclusion criteria: 1. Patients did not collect saliva samples between 8:00 and 10:00 am; 2. Major organ dysfunction including severe liver dysfunction (Child-Pugh class B or C, or ALT/AST > 3 times the upper limit of normal); Severe renal insufficiency (estimated glomerular filtration rate eGFR < 30 mL/min/1.73m^2); 3. known pituitary or hypothalamic lesions, primary gonadal disease (e.g., Klineuelsson's syndrome), uncontrolled thyroid dysfunction; 4. Is receiving, or has received within the past 3 months, testosterone replacement therapy, gonadotropin therapy, antiandrogen therapy, or systemic glucocorticoids (at any dose for more than 2 weeks). Use of medications that may significantly affect testosterone levels (e.g., high-dose opioids, certain antipsychotics, etc.) within the past 6 months; 5. Severe ED due to definite organic causes without expected response to PDE5i therapy (e.g., after radical pelvic surgery or radiotherapy, severe pelvic nerve injury, congenital malformation); 6. Patients with serious mental illness (such as severe depression, schizophrenia), which is judged by the investigator to be unable to reliably complete the questionnaire or affect the assessment of sexual function; 7. According to the investigator's judgment, he was not suitable to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Salivary free testosterone levels;The serum hormone free testosterone; | — |
Secondary
| Measure | Time frame |
|---|---|
| International Index of Erectile Function-5 (IIEF-5) scoring scale score;Body mass Index (BMI);Glycosylated hemoglobin; | — |
Countries
China
Contacts
Public ContactCao Ying
Southern Medical University Southern Hospital
Outcome results
None listed