Stroke
Conditions
Interventions
Precision tDCS Group:After enrollment, participants will first undergo an upper-limb
somatosensory evoked potential (USEP) test to record the N20 amplitudes on the affected and unaffected sides (pre-t
stimulation intensity will be 2 mA for 20 minutes per session. Immediately after stimulation, USEP will be repeated to re-measure bilateral N20 amplitudes and compare the pre- vs post-tDCS changes.
Tr
(2) If the affected-side N20 amplitude decreases and the affected-to-unaffected N20 amplitude ratio decreases, participants will be categorized as the "compensatory recovery model" and will receive an
Hemispheric Inhibition tDCS Group:Cathodal tDCS will be applied over the primary somatosensory cortex of the unaffected hemisphere. Stimulation parameters will be standardized as 2 mA for 20 minutes p
Sham tDCS Group:A 20-minute sham tDCS session will be
Sponsors
Wuxi Second Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. First-ever, unilateral stroke confirmed by cranial computed tomography (CT) or magnetic resonance imaging (MRI). 2. Age 18–85 years. 3. Duration since stroke onset between 14 days and 1 year. 4. Presence of hemiplegia and unilateral sensory impairment (at screening, impairment in at least one of the following: superficial sensation, proprioception, or cortical/combined sensation). 5. Clinically stable with no severe complications. 6. Mini-Mental State Examination (MMSE) score > 21. 7. Received conservative treatment after stroke and did not undergo craniotomy or other neurosurgical procedures. 8. Voluntary participation and written informed consent provided.
Exclusion criteria
Exclusion criteria: 1. History of epilepsy or a family history of epilepsy. 2. Metal implants in the skull/head or an implanted cardiac pacemaker. 3. Cognitive impairment. 4. Communication difficulties, including aphasia or severe dysarthria. 5. Severe internal medical diseases (e.g., hepatic or renal insufficiency). 6. Peripheral nerve injury of the upper limb. 7. Pregnancy, breastfeeding, or concurrent participation in another clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Upper-limb somatosensory evoked potential (SEP) N20 affected-to-unaffected amplitude ratio; | — |
Secondary
| Measure | Time frame |
|---|---|
| Semmes-Weinstein;Two-point discrimination;Erasmus MC revised Nottingham sensory assessment scale, Em-NSA;Pain scale; | — |
Countries
China
Contacts
Public ContactHeng Jingjing
Wuxi Second Hospital of Traditional Chinese Medicine
Outcome results
None listed