None
Conditions
Interventions
Routine Management Group: Individuals who underwent "routine or non-standardized early warning and follow-up" during the period from October 2021 to January 2026, prior to the implementation of the st
Intervention Group: All individuals enrolled in the health examination program after the formal implementation of the system in February 2026, who received "standardized early warning and active follo
Sponsors
West China Tianfu Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Adults (>=18 years) who, during the specified study period, undergo health examinations at our center and are identified as having "critical abnormal findings." The definition of "critical abnormal findings" is based on the Expert Consensus on Management of Critical Abnormal Findings in Health Examinations, including but not limited to: Category A (Requiring Emergency Intervention): e.g., electrocardiographic findings suggestive of acute myocardial infarction, CT findings indicating cerebral hemorrhage, severe hyperkalemia (serum potassium >= 6.5 mmol/L). Category B (Requiring Specialist Referral): e.g., imaging findings suspicious for malignancy (e.g., pulmonary nodules = 8 mm with malignant features, thyroid nodules classified as TI-RADS 4 or higher), gastric biopsy pathology showing high-grade intraepithelial neoplasia. Category C (Requiring Regular Monitoring): e.g., fasting blood glucose >= 13.9 mmol/L, estimated glomerular filtration rate (eGFR) < 30 mL/min/1.73 m². 2. Participants must also have available contact information to enable follow-up.
Exclusion criteria
Exclusion criteria: 1. For the retrospective cohort: records with missing data exceeding 30% for key variables (e.g., details of abnormal findings, contact information, whether medical consultation was sought). 2. For the prospective cohort: Individuals unable or unwilling to provide informed consent; 3. Those whose detected abnormalities are already confirmed as previously known conditions under stable follow-up, with no need for changes in management based on the current alert; 4. Individuals with severe mental illness, cognitive impairment, or absence of a legal guardian, rendering them unable to engage in basic communication.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of the composite endpoint of cancer and major adverse cardiovascular and cerebrovascular events (MACE).;Early treatment rate for critical abnormal findings.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Effective alert information receipt rate.;Detection rate and composition ratio of critical abnormal findings.;All-cause mortality.;Patient anxiety level score;Patient satisfaction score;Loss to follow-up rate/Adherence; | — |
Countries
China
Contacts
Public ContactHuairong Tang
West China Tianfu Hospital, Sichuan University
Outcome results
None listed