Heart failure disease
Conditions
Interventions
Sponsors
Shanxi Bethune Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Inclusion criteria for patients with heart failure: (1) aged >=18 years; signed informed consent; (2) diagnosis of heart failure confirmed by physical examination, laboratory testing, and echocardiography in accordance with the criteria of the American College of Cardiology (ACC) and the American Heart Association (AHA). Heart failure with preserved ejection fraction (HFpEF) was defined as EF >=50%; heart failure with reduced ejection fraction (HFrEF) was defined as EF =18 years; (2) patients concurrently hospitalized in the same department who, according to ACC/AHA criteria, are in a pre-heart-failure or preclinical stage of heart failure (i.e., have HF risk factors or structural heart disease but no clinical symptoms of HF), and in whom heart failure was excluded on clinical evaluation.
Exclusion criteria
Exclusion criteria: 1.At enrollment: acute myocardial infarction, malignant (life-threatening) cardiac arrhythmias, congenital or valvular heart disease, acute cerebrovascular disease, severe infectious diseases, hematologic disorders, malignancies, or autoimmune diseases; 2.Moderate to severe renal dysfunction [eGFR <=60 mL/min/1.73 m2] or receipt of renal replacement therapy; 3.Hepatic dysfunction (Child-Pugh class A or higher); 4.Use of antibiotics within 4 weeks prior to enrollment; 5.Undergoing open-heart surgery within 4 weeks prior to enrollment; 6.Pregnancy, lactation, or planning pregnancy during the study period; 7.Inability to complete 12 months of follow-up, or presence of other major diseases or conditions that could potentially affect study outcomes.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Composite endpoint of cardiovascular death (sudden cardiac death, acute myocardial infarction, heart failure, cardiovascular surgery, or other cardiovascular causes) or heart transplantation; | — |
Secondary
| Measure | Time frame |
|---|---|
| All-cause mortality;Worsening heart failure;First hospitalization due to cardiovascular causes; | — |
Countries
China
Contacts
Public ContactLi Li
Shanxi Bethune Hospital
Outcome results
None listed