Chronic kidney disease
Conditions
Interventions
Gold Standard:Percentage of interstitial fibrosis and tubular atrophy in renal cortical biopsy pathology
Index test:Joint model of STVi and SR-CEUS
Sponsors
Peking University Shenzhen Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >=18 years old; Patients were in stable clinical condition and could cooperate with ultrasound examination (able to complete short-term breath holding/breathing cooperation, lying flat or on the side), and signed informed consent. 2. Consistent with the diagnosis of CKD; 3. Renal biopsy specimens with at least 8 glomeruli that could be evaluated under light microscopy and sufficient renal cortex to complete the IFTA proportion estimation; 4. Routine ultrasound, STVi and SR-CEUS were performed within one week after renal biopsy. 5. Complete baseline data (including but not limited to Scr/eGFR, urinary albumin/proteinuria, blood pressure, and main medications) were available;
Exclusion criteria
Exclusion criteria: 1. Acute kidney injury or acute exacerbation requiring urgent management has an "acute/rapidly progressive state" that may lead to short-term pathology-imaging mismatch or significant intervention bias; 2. Initiation or significant adjustment of immunosuppressive/hormonal therapies that affect the inflammation-fibrosis phenotype within 1 week before or after biopsy or ultrasound examination; 3. Incomparable measurement or obvious confounding factors caused by anatomical structure/hemodynamic factors, such as renal artery stenosis or renal artery stenosis indicated by ultrasound/Doppler; Urinary obstruction/hydronephrosis; Renal tumors, multiple renal cysts, tumors, etc.; 4. Contraindications of SonoVue venography: allergy to components, known right-to-left shunt, severe pulmonary hypertension (pulmonary arterial pressure >90 mmHg), uncontrolled systemic hypertension, ARDS, etc. 5. Pregnancy; 6. Other conditions affecting the reproducibility: extreme obesity (BMI>35 kg/m^2) or poor acoustic window that prevented effective ROI acquisition, investigator's judgment that they were not suitable for enrollment or could not complete the follow-up; 7. Image quality control was not up to standard. Renal lesions seriously affect the accuracy of measurement: multiple renal cysts, multiple renal calculi, renal dysplasia, renal mass, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pathological biopsy showed mild fibrosis;Pathological biopsy showed moderate to severe fibrosis; | — |
Countries
China
Contacts
Public ContactZhu Yixin
Peking University Shenzhen Hospital
Outcome results
None listed