Community-acquired pneumonia
Conditions
Interventions
Influenza A-bacterial co-infection:None
Sponsors
Fuzhou University Affiliated Provincial Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Meet the primary screening criteria: (1) Adult patients over 18 years old; (2) The clinical diagnosis was community-acquired pneumonia, which met the diagnostic criteria of ATS/IDSA; (3) Influenza A virus was confirmed positive by RT-PCR; (4) Admission within 7 days of onset; (5) Sign the informed consent form; (6) Expected hospitalization time >= 48 hours. 2. Diagnostic criteria of bacterial infection (meet any of the following conditions): (1) positive blood culture (2) positive sputum culture (qualified sputum specimen) (3) positive bronchoalveolar lavage fluid culture (4) positive bacterial PCR detection (5) procalcitonin >= 0.25ng/mL and effective antibacterial treatment. 3. Have complete dynamic monitoring data within 48 hours.
Exclusion criteria
Exclusion criteria: 1.patients with immunodeficiency diseases (HIV infection, primary immunodeficiency disease, etc.); 2. Malignant tumor patients (within 3 years); 3. Long-term use of immunosuppressants (> 3 months); 4. Severe hepatic and renal insufficiency (Child-pugh grade C or serum creatinine > 300µ mol/L); 5. Pregnant or lactating women; 6. Patients whose expected survival time is less than 3 months; 7. Patients who cannot obtain informed consent or have poor compliance; 8. Previous participation in other clinical trials that may affect the results of this study, or other uncertain factors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| GZMB; | — |
Secondary
| Measure | Time frame |
|---|---|
| Inflammation markers (CRP, PCT, IL-6, TNF-a, IL-1ß, etc.);Immune markers (GNLY, IL-7, etc.); | — |
Countries
China
Contacts
Public ContactLong Huang
Fuzhou University Affiliated Provincial Hospital
Outcome results
None listed