The acceleration of biological aging induced by prolonged sleep deprivation
Conditions
Interventions
Trial Group:Haematococcus pluvialis astaxanthin capsules, 16mg/d, oral, once daily, taken after dinner
Control Group:Placebo (identical in appearance, color, and packaging, containing no astaxanthin or other antioxidant active ingredients)
Sponsors
Shanghai Sixth People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 59 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 59; 2. Working adults with long-term sleep deprivation, including those who have slept less than 7 hours a day for the last 6 months and those with long-term sleep less than 7 hours due to frequent night shifts; 3. Those with accelerated biological aging at baseline; 4. People who do not take antioxidants regularly on a daily basis; 5. Those who voluntarily participate in the trial and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with tumors, autoimmune diseases, or severe conditions affecting the heart, liver, kidneys, hematopoietic system, or psychiatric disorders; 2. Smokers; 3. Pregnant or lactating women, and women planning pregnancy; 4. Individuals allergic to the study sample; 5. Individuals unable to take the study sample as directed.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Biological aging markers; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sleep quality;Chronic systemic inflammatory markers (CRP, hsCRP, IL-2, IL-1ß, IL-6, TNF-a);Metabolic markers (glucose-related and lipid-related parameters);Body composition; | — |
Countries
China
Contacts
Public ContactHua Shuyao
Shanghai Sixth People's Hospital
Outcome results
None listed