sepsis
Conditions
Interventions
Amino Acid-Based Elemental Enteral Nutrition Group:None
Intact Protein-Based Enteral Nutrition Group:None
Sponsors
Beijing Chaoyang Hospital Affiliated to Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. age >= 18 years; 2. meets the 2021 diagnostic criteria for sepsis 3.0; 3. expected ICU stay >= 48 hours; 4. have an indication for nutritional support (nutritional screening for risk of malnutrition NRS2002 >= 3 points) and require enteral nutritional support; 5. The patient or family member understands the study protocol and is willing to participate in the study by providing written informed consent.
Exclusion criteria
Exclusion criteria: 1. those with a history of allergy to components in enteral nutrition; 2. those with severe disorders of the internal environment; 3. patients with severe diabetes mellitus, patients taking large amounts of steroids; 4. Pregnant and lactating women; 5. patients with abnormal amino acid metabolism; 6. uncontrolled shock, not yet haemodynamically stable or inadequate tissue perfusion; 7. uncontrolled fatal hypoxaemia, hypercapnia or acidosis; 8. presence of active upper gastrointestinal bleeding, significant gastrointestinal ischaemia, high-flow small bowel fistula, abdominal septal compartment syndrome; 9. gastrointestinal decompression drainage >= 500 ml/6h; 10. has been on parenteral nutritional support for >3 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| T and B lymphocyte subsets;levels of inflammatory cytokines;HLA-DR expression on immune cells;Lymphocyte count; | — |
Secondary
| Measure | Time frame |
|---|---|
| Nutritional status parameters;ICU length of stay;Duration of mechanical ventilation;Duration of antibiotic therapy;28-day all-cause mortality after enrollment;Occurrence and timing of new-onset infections;Energy delivery adequacy rate; | — |
Countries
China
Contacts
Public ContactNa Cui
Beijing Chaoyang Hospital Affiliated to Capital Medical University
Outcome results
None listed