Traumatic symptoms with major depressive disorder
Conditions
Interventions
Treatment Group:Accelerated intermittent theta burst stimulation (a-iTBS) administered five times daily for approximately three minutes per session, with 50-minute intervals between sessions, over fiv
Control Group:A sham stimulation with identical parameters but vertically positioned coils was employed as a control.
Sponsors
Beijing Huilongguan Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
12 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. Aged 12–18 years, right-handed; 2. Meets ICD-10 diagnostic criteria for moderate depressive episode, with current depressive episode lasting at least 4 weeks; 3. HAMD (17-item) score: total >=17 points; 4. Positive CTQ scale screening, defined as: Emotional Abuse >=13 points OR Physical Abuse >=10 points OR Sexual Abuse =8 points OR Emotional Neglect >=15 points OR Physical Neglect >=10 points; 5. Stable use of a single selective serotonin reuptake inhibitor (SSRI) antidepressant for at least 15 days prior to enrolment (with no changes in drug type or dosage), or no prior use of any antidepressant medication; 6. Informed consent obtained from both the patient and guardian, with signed consent forms.
Exclusion criteria
Exclusion criteria: 1. Patients with bipolar disorder, alcohol use disorder, or substance use disorder; depressive states arising from other systemic diseases or organic brain lesions; 2. Presence of metallic implants such as dentures, aneurysm clips, cardiac pacemakers, or metallic fixations; 3. Individuals who have undergone systemic TMS or electroconvulsive therapy within the preceding three months; 4. Patients with treatment-resistant depression (TRD); 5. Presence of contraindications to TMS treatment; 6. Individuals currently undergoing systematic psychotherapy; 7. Those exhibiting severe agitation, risk of suicide or self-harm, or impulsive non-compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Scale (HAMD-17); | — |
Secondary
| Measure | Time frame |
|---|---|
| Patient Health Questionnaire-9 (PHQ-9);Generalized Anxiety Disorder-7 (GAD-7);Posttraumatic Stress Disorder Checklist for DSM-5 (PCL-5);Clinician Administered PTSD Scale (CAPS);International Trauma Questionnaire – Child and Adolescent Version (ITQ-CA);Ruminative Responses Scale (RRS);Deliberate Self-Harm Ideation Scale for Adolescents Revised Version (DSHI-AR);DSHI-AR (Thoughts);Ottawa Self-Injury Inventory – Addictive Subscale (OSI-Addictive);The Affective Reactivity Index (ARI-S / ARI-P);Brief Irritability Test (BITe);Blinding Assessment;Resting-state functional connectivity strength between prefrontal cortex and amygdala;High-frequency neural oscillation power in Magnetoencephalography (MEG); | — |
Countries
China
Contacts
Public ContactXiaohong Li/Xinpeng Xu
Beijing Huilongguan Hospital, Capital Medical University
Outcome results
None listed