Symptomatic intracranial arterial stenosis
Conditions
Interventions
Tirofiban group:Postoperatively, Tirofiban will be administered immediately at 0.2 µg/kg/min for 30 minutes, followed by a maintenance infusion of 0.05 µg/kg/min for 11.5 hours, in addition to standar
Conventional treatment group:Standard postoperative medical therapy will be administered.
Sponsors
Huashan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. 30 years <= age <= 80 years; 2. intracranial symptomatic atherosclerosis (ischaemic event including TIA or ischaemic stroke within the last 12 months. and that ischaemic event was associated with intracranial atherosclerosis (70-99% stenosis) including internal carotid artery - segment C7, middle cerebral artery - segment M1, basilar artery, vertebral artery segments V3 and V4)); 3. angioplasty (including stenting and/or balloon dilatation) 3 weeks after the ischaemic event; 4. immediate postoperative CT to exclude intracranial haemorrhage, subarachnoid haemorrhage, and subdural/extradural haemorrhage; 5. signing an informed consent form;
Exclusion criteria
Exclusion criteria: 1. Possess any contraindication to intracranial angioplasty 2. CT/MRI suggesting previous large cerebral infarction 3. Bleeding from the urinary tract or gastrointestinal tract within the last 30 days. 4. Major surgery within the last 14 days 5. Known history of coagulation disorders, platelet abnormalities or thrombocytopenia 6. Allergy to tirofiban 7. Platelet count = 220umol/L) 9. Life expectancy <1 year with serious diseases 10. Postoperative entrapment of diseased vessels or other imaging manifestations of high thrombotic risk. 11. Patient participation in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of symptomatic ischemic stroke within 72 hours after enrollment;Incidence of symptomatic intracranial hemorrhage (sICH) within 72 hours after enrollment;Incidence of new hyperintense lesions on diffusion-weighted MRI (DWI) within 72 hours after enrollment; | — |
Secondary
| Measure | Time frame |
|---|---|
| New-onset hemorrhagic stroke events within 30 days after enrollment;Systemic bleeding events within 72 hours after enrollment (e.g., gastrointestinal bleeding, access-site bleeding);New-onset ischemic stroke events within 30 days after enrollment; | — |
Countries
China
Contacts
Public ContactYuxiang Gu
Huashan Hospital, Fudan University
Outcome results
None listed