Adenoid cystic carcinoma of the head and neck
Conditions
Interventions
Postoperative concurrent chemoradiotherapy group:None
Postoperative radiotherapy alone group:None
Surgery-only group:None
Postoperative chemotherapy only group:None
Sponsors
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
15 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 15-80 years (inclusive of 15 and 80 years); 2. Histologically diagnosed with adenoid cystic carcinoma of the head and neck, without distant metastasis; 3. Radiotherapy methods include static or dynamic intensity-modulated radiotherapy, with a planned cumulative radiation dose of >= 60 Gy; the concurrent chemotherapy drug is cisplatin; 4. No previous radiotherapy or chemotherapy for head and neck tumors; 5. ECOG score: 0-2; 6. Good function of major organs, that is, within 14 days before randomization, the relevant test indicators meet the following requirements: a. Blood routine examination: hemoglobin >= 80 g/L (no blood transfusion within 14 days); neutrophil count > 1.5×10^9/L; platelet count >= 80×10^9/L; b. Biochemical examination: total bilirubin = 60 ml/min (Cockcroft-Gault formula); 7. Cardiac Doppler ultrasound assessment: left ventricular ejection fraction (LVEF) >= 50%
Exclusion criteria
Exclusion criteria: 1.Previously received radiation therapy or chemotherapy for head and neck tumors; 2.Patients receiving neoadjuvant therapy before surgery; 3.Complicated with serious heart, lung, liver, kidney, digestive system, hematopoietic system and nervous system diseases, acute infectious diseases, autoimmune diseases, HIV, Poor blood sugar control; 4.Pregnant or lactating female; 5.Allergic constitution (such as those known to be allergic to two or more drugs); 6.Patients with severe mental illness, a history of alcohol or drug abuse;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall Survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| Progression-free survival; | — |
Countries
China
Contacts
Public ContactKunyu Yang
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed