Perioperative myocardial injury
Conditions
Interventions
Active ta-VNS group:In the active ta-VNS group, patients will undergo stimulation of the left cymba conchae. Stimulation will be delivered at a frequency of 25 Hz and a pulse width of 250 µs, with a d
Sham ta-VNS group:In the sham stimulation group, participants will undergo the same intervention protocol
however, the electrical stimulation device will be powered off after the intensity adjustment procedure. All devices will be labeled to ensure that each participant uses the same device throughout all
Sponsors
Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University
Eligibility
Sex/Gender
All
Age
40 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Age between 40 and 85 years; 2. Scheduled for elective mitral and/or aortic valve surgery under general anesthesia with cardiopulmonary bypass, with or without concomitant tricuspid valve procedures; 3. Physical status classification I–III according to the American Society of Anesthesiologis 4. Functional class I–III according to the New York Heart Association; 5. Provided written informed consent and agreed to participate in the study.
Exclusion criteria
Exclusion criteria: 1. Left ventricular ejection fraction (LVEF) 0.3 µg/kg/min); 8. Cerebrovascular events within the preceding 6 months; 9. Epileptic seizures or recurrent syncope within the past 5 years; 10. Exposure to vagus nerve stimulation or acupuncture therapy within 1 month before study enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| hs-cTn I; | — |
Secondary
| Measure | Time frame |
|---|---|
| hs-cTn I;NT-proBNP;CK-MBm;Inflammatory markers (WBC, CRP);creatinine; | — |
Countries
China
Contacts
Public ContactZhang Jun
Department of Anesthesiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University
Outcome results
None listed