Postoperative Analgesia for Myomectomy
Conditions
Interventions
Dexmedetomidine Group (Dexmedetomidine + Sufentanil):None
Esketamine Group (Esketamine+ Sufentanil):None
Sponsors
Xiangyang No.1 People's Hospital,Hubei University of Medicin
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Female, aged 18-65 years (inclusive). 2. American Society of Anesthesiologists (ASA) physical status I-III. 3. Scheduled for elective laparoscopic myomectomy under general anesthesia (which may be combined with nerve block according to clinical needs), and planned for postoperative patient-controlled intravenous analgesia (PCIA) using either dexmedetomidine combined with sufentanil or esketamine combined with sufentanil. 4. Normal preoperative neurological and cognitive function. 5. Ability to understand the Visual Analog Scale (VAS) for pain and willingness to cooperate with follow-up assessments. 6. Voluntary participation by the patient or their legal guardian, with signed informed consent obtained.
Exclusion criteria
Exclusion criteria: 1. Known or suspected allergy or contraindications to any component of dexmedetomidine or esketamine; or history of opioid abuse or addiction. 2. Pre-existing sleep disorders, cognitive impairment, diagnosed delirium; or uncontrolled psychiatric illness; or history of psychoactive substance abuse. 3. Coexisting severe cardiovascular or cerebrovascular disease, severe respiratory disease, major organ failure, coagulation disorders, immune system diseases, or uncontrolled severe endocrine disorders; or organic central nervous system diseases; or impaired consciousness at screening. 4. Pregnant or lactating women. 5. Severe visual or hearing impairment that prevents cooperation with assessments and follow-up. 6. Any other conditions considered by the investigator as unsuitable for participation in this study (e.g., planned postoperative ICU admission, participation in other drug clinical trials within 4 weeks prior to screening).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual Analog Scale (VAS) for pain assessed at 1 day before surgery and 24 hours after surgery.;Ramsay assessed at 1 day before surgery and 24 hours after surgery.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Anxiety scores assessed at 1 day before surgery and at 1 and 3 days after surgery;Sleep scores assessed at 1 day before surgery and at 1 and 3 days after surgery.;Mental status scores assessed at 1 day before surgery and at 1 and 7 days after surgery; | — |
Countries
China
Contacts
Public ContactHuiyu Luo
Xiangyang No.1 People's Hospital,Hubei University of Medicin
Outcome results
None listed