Unexplained Recurrent Spontaneous Abortion
Conditions
Interventions
exposed group:None
Sponsors
The first affiliated hostipal of nanchang university
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. A history of >= 2 consecutive spontaneous abortions, meeting the diagnostic criteria for URSA as outlined in the Expert Consensus on the Diagnosis and Treatment of Recurrent Spontaneous Abortion (2022). 2. Age between 18 and 45 years. 3. Planning to conceive naturally or already naturally pregnant with a gestational age <=6 weeks. 4. Completed a standardized etiological workup (including chromosomes, anatomy, coagulation/immunity, endocrinology, infection, male factors, and environmental/psychological factors) with no cause identified. 5. Signed informed consent form.
Exclusion criteria
Exclusion criteria: 1. Presence of a clear, specific etiological factor (e.g., embryonic or parental chromosomal abnormalities, significant uterine malformations, uncontrolled thyroid disease or diabetes, antiphospholipid syndrome (APS), etc.). 2. Comorbidity with severe heart, brain, liver, kidney, hematopoietic, or psychiatric diseases or recent use of potent immunosuppressive agents that could affect the study's outcome assessment. 3. Unwillingness to be followed up or poor anticipated compliance. 4. Any other condition that, in the investigator's judgment, makes the patient unsuitable for participation in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to Pregnancy;live birth; | — |
Secondary
| Measure | Time frame |
|---|---|
| Drug-related adverse events;12 or 24-month cumulative pregnancy rate; | — |
Countries
China
Contacts
Public Contactrui wu
The first affiliated hostipal of nanchang university
Outcome results
None listed